Immunization with recombinant LD1 antigens protects against experimental leishmaniasis

被引：37

作者：

Dole, VS

Raj, VS

Ghosh, A

Madhubala, R

Myler, PJ

Stuart, KD ^{[1
]}

机构：

[1] Jawaharlal Nehru Univ, Sch Life Sci, New Delhi 110067, India

[2] Seattle Biomed Res Inst, Seattle, WA 98109 USA

[3] Univ Washington, Dept Pathobiol, Seattle, WA 98195 USA

来源：

VACCINE | 2000年 / 19卷 / 4-5期

关键词：

Leishmania donovani; recombinant antigen; vaccination;

D O I：

10.1016/S0264-410X(00)00207-3

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The genes, ORFF and BT1 (previously ORFG), are part of the multigenic LD1 locus on chromosome 35 which is frequently amplified in Leishmania. BT1 encodes a biopterin transporter, while the function of the ORFF gene product is unknown, but it is localized to the nucleus. We show here that immunization of mice with recombinant ORFF and BT1 proteins, individually, or in combination, conferred partial protection against challenge with Leishmania donovani. Protection correlated with the production of antigen-specific antibodies and in vitro splenocyte proliferation. Thus, these antigens can be potential vaccine candidates against Visceral leishmaniasis. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：423 / 430

页数：8

共 47 条

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[2]

BURNS JM, 1991, J IMMUNOL, V146, P742

[3] IMMUNOLOGICAL MARKERS OF CLINICAL EVOLUTION IN CHILDREN RECENTLY INFECTED WITH LEISHMANIA-DONOVANI-CHAGASI [J].