Neuronal apoptosis in rats is accompanied by rapid impairment of cellular respiration and is prevented by scavengers of reactive oxygen species

被引：52

作者：

Atlante, A

Gagliardi, S

Marra, E

Calissano, P

机构：

[1] CNR, Ist Neurobiol, I-00137 Rome, Italy

[2] Univ Bari, Dipartmento Biochim & Biol Mol, I-70126 Bari, Italy

[3] CNR, Ctr Studio Mitocondri & Metab Energet, I-70126 Bari, Italy

来源：

NEUROSCIENCE LETTERS | 1998年 / 245卷 / 03期

关键词：

apoptosis; low [K+; cerebellar granule cells; mitochondria; bioenergetics; reactive oxygen species scavengers;

D O I：

10.1016/S0304-3940(98)00195-5

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Apoptosis of cerebellar granule cells induced by potassium withdrawal is accompanied by a very rapid decrease in both cell and mitochondrial respiration supported by glucose and succinate, respectively. The respiratory control ratio, which is an index of oxidative phosphorylation and therefore reflects the ability of mitochondria to produce ATP, is reduced by 50% within the first 2 h after the beginning of apoptosis, insulin-like growth factor I (IGF-I), actinomicin D or cycloheximide, previously reported to inhibit apoptosis, fully prevent the impairment of cellular respiration while scavengers of reactive oxygen species partially inhibit apoptosis and restore cellular respiration. (C) 1998 Elsevier Science Ireland Ltd.

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收藏

页码：127 / 130

页数：4

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