Vesicular osmometers, vasopressin secretion and aquaporin-4: A new mechanism for osmoreception?

被引：46

作者：

Wells, T ^{[1
]}

机构：

[1] Univ Wales, Sch Mol & Med Biosci, Physiol Unit, Cardiff CF1 3US, S Glam, Wales

来源：

MOLECULAR AND CELLULAR ENDOCRINOLOGY | 1998年 / 136卷 / 02期

基金：

英国医学研究理事会;

关键词：

osmoreceptors; vasopressin; aquaporins; aquaporin-4; mercurial-insensitive water channel;

D O I：

10.1016/S0303-7207(97)00219-0

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

This review cites new evidence suggesting a link between the recently discovered membrane bound water-selective channel, aquaporin-4 (AQP4), and the mechanism of central osmoreception. AQP4 is found in a number of brain regions associated with the osmoregulation of vasopressin secretion and thirst, including the supraoptic nucleus (SON) and subfornical organ (SFO). AQP4 expression is restricted to ependymal cell membranes in the SFO and astrocyte membranes in the SON, especially perivascular end foot processes, suggesting that glial cells may correspond to Verney's hypothalamic 'vesicular osmometers'. Information on osmotic status may thus be conveyed to the neuronal elements of the 'osmoreceptor complex' by a neurone-glial interaction. (C) 1998 Elsevier Science Ireland Ltd.

引用

页码：103 / 107

页数：5

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