The Bcl-2 protein family: sensors and checkpoints for life-or-death decisions

被引：594

作者：

Borner, C ^{[1
]}

机构：

[1] Univ Freiburg, Inst Mol Med & Cell Res, Freiburg, Germany

来源：

MOLECULAR IMMUNOLOGY | 2003年 / 39卷 / 11期

关键词：

apoptosis; Bcl-2; bax; BH3-only; mitochondria; caspases; caspase-independent; lymphocyte survival;

D O I：

10.1016/S0161-5890(02)00252-3

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Members of the Bcl-2 family are crucial integrators of survival and death signals in higher eukaryotes. Although recent studies have provided novel and quite unexpected insights into the mechanisms by which these proteins might issue life permits or death sentences in cells, we are still on the way to fully understand their modes of action. This review provides a snapshot on where we are on this journey and how we may exploit our knowledge on this family of proteins to unveil the mysteries of immune regulation. (C) 2003 Elsevier Science Ltd. All rights reserved.

引用

页码：615 / 647

页数：33

共 314 条

[1] Three-dimensional structure of the apoptosome: Implications for assembly, procaspase-9 binding, and activation [J].

Acehan, D ;

Jiang, XJ ;

Morgan, DG ;

Heuser, JE ;

Wang, XD ;

Akey, CW .

MOLECULAR CELL, 2002, 9 (02) :423-432

[2] Life-or-death decisions by the Bcl-2 protein family [J].

Adams, JM ;

Cory, S .

TRENDS IN BIOCHEMICAL SCIENCES, 2001, 26 (01) :61-66

[3] The Bcl-2 protein family: Arbiters of cell survival [J].

Adams, JM ;

Cory, S .

SCIENCE, 1998, 281 (5381) :1322-1326

[4] Regulation of apoptotic protease activating factor-1 oligomerization and apoptosis by the WD-40 repeat region [J].

Adrain, C ;

Slee, EA ;

Harte, MT ;

Martin, SJ .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (30) :20855-20860

[5] Apoptosis-associated release of Smac/DIABLO from mitochondria requires active caspases and is blocked by Bcl-2 [J].

Adrain, C ;

Creagh, EM ;

Martin, SJ .

EMBO JOURNAL, 2001, 20 (23) :6627-6636

[6] THE SIGNIFICANCE OF LOW BCL-2 EXPRESSION BY CD45RO-T-CELLS IN NORMAL INDIVIDUALS AND PATIENTS WITH ACUTE VIRAL-INFECTIONS - THE ROLE OF APOPTOSIS IN T-CELL MEMORY [J].

AKBAR, AN ;

BORTHWICK, N ;

SALMON, M ;

GOMBERT, W ;

BOFILL, M ;

SHAMSADEEN, N ;

PILLING, D ;

PETT, S ;

GRUNDY, JE ;

JANOSSY, G .

JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 178 (02) :427-438

[7] Bax and other pro-apoptotic Bcl-2 family "killer-proteins" and their victim, the mitochondrion [J].

Antonsson, B .

CELL AND TISSUE RESEARCH, 2001, 306 (03) :347-361

[8] Bax oligomerization is required for channel-forming activity in liposomes and to trigger cytochrome c release from mitochondria [J].

Antonsson, B ;

Montessuit, S ;

Lauper, S ;

Eskes, R ;

Martinou, JC .

BIOCHEMICAL JOURNAL, 2000, 345 :271-278

[9] Bax is present as a high molecular weight oligomer/complex in the mitochondrial membrane of apoptotic cells [J].

Antonsson, B ;

Montessuit, S ;

Sanchez, B ;

Martinou, JC .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2001, 276 (15) :11615-11623

[10] Crystal structure of rat Bcl-x(L) - Implications for the function of the Bcl-2 protein family [J].

Aritomi, M ;

Kunishima, N ;

Inohara, N ;

Ishibashi, Y ;

Ohta, S ;

Morikawa, K .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (44) :27886-27892

← 1 2 3 4 5 6 7 8 9 10 →