Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis

被引：527

作者：

Chan, TA

Morin, PJ

Vogelstein, B

Kinzler, KW

机构：

[1] Johns Hopkins Univ, Sch Med, Ctr Oncol, Baltimore, MD 21231 USA

[2] Johns Hopkins Univ, Sch Med, Howard Hughes Med Inst, Baltimore, MD 21231 USA

来源：

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA | 1998年 / 95卷 / 02期

关键词：

D O I：

10.1073/pnas.95.2.681

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Nonsteroidal antiinflammatory drugs (NSAIDs) can inhibit colorectal tumorigenesis and are among the few agents known to be useful for the chemoprevention of neoplasia. Here, we show that the tumor suppressive effects of NSAIDs are not likely to be related to a reduction in prostaglandins but rather are due to the elevation of the prostaglandin precursor arachidonic acid (AA). NSAID treatment of colon tumor cells results in a dramatic increase in AA that in turn stimulates the conversion of sphingomyelin to ceramide, a known mediator of apoptosis. These results have significant implications for understanding and improving colon cancer chemoprevention.

引用

页码：681 / 686

页数：6

共 43 条

[1] Membrane unpacking and the rapid disposal of apoptotic cells [J].