Nitric oxide's reactions with hemoglobin: a view through the SNO-storm

被引：231

作者：

Gladwin, MT ^{[1
]}

Lancaster, JR

Freeman, BA

Schechter, AN

机构：

[1] NIDDKD, Dept Crit Care Med, Warren G Magnuson Clin Ctr, NIH, Bethesda, MD 20892 USA

[2] NIDDKD, Biol Chem Lab, NIH, Bethesda, MD 20892 USA

[3] Univ Alabama Birmingham, Dept Anesthesiol, Birmingham, AL USA

[4] Univ Alabama Birmingham, UAB Ctr Free Rad Biol, Birmingham, AL USA

来源：

NATURE MEDICINE | 2003年 / 9卷 / 05期

关键词：

D O I：

10.1038/nm0503-496

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

S-nitroso-hemoglobin (SNOHb) has been proposed to regulate blood flow and tissue oxygenation through allosterically controlled binding and delivery of nitric oxide (NO) and oxygen in the vasculature. This precept and the experiments that test it have provoked both ardent support and expanding dissent. An alternative view suggests that a physiologically tightly regulated balance of NO scavenging by hemoglobin and NO production by endothelial cells determines NO bioavailability.

引用

页码：496 / 500

页数：5

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