New drugs for epilepsy

被引：24

作者：

Sander, JWAS

机构：

[1] UCL Natl Hosp Neurol & Neurosurg, Inst Neurol, London WC1N 3BG, England

[2] Natl Soc Epilepsy, Gerrards Cross, Bucks, England

来源：

CURRENT OPINION IN NEUROLOGY | 1998年 / 11卷 / 02期

关键词：

D O I：

10.1097/00019052-199804000-00011

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Seizure freedom with no side-effects is the aim of treatment, and new antiepileptic drugs have not lived up to expectations; only a few patients with chronic epilepsy have been rendered seizure-free. These treatments have side-effects but their safety profile may be better than older alternatives, although chronic effects have not yet been established. This article reviews newly marketed antiepileptic drugs. It concentrates on shortcomings of current antiepileptic treatment and on the way drugs are developed. A new approach to treatment is long overdue. The development of rational antiepileptic treatments should be strongly encouraged. More clinically relevant paradigms need to be developed and incorporated into clinical trial programmes as these are presently biased in their designs towards regulatory issues. (C) 1998 Rapid Science Ltd.

引用

页码：141 / 148

页数：8

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