Does ADMA cause endothelial dysfunction?

被引：495

作者：

Cooke, JP ^{[1
]}

机构：

[1] Stanford Univ, Sch Med, Div Cardiovasc Med, Sect Vasc Med,CVCR,Falk Cardiovasc Res Ctr, Stanford, CA 94305 USA

来源：

ARTERIOSCLEROSIS THROMBOSIS AND VASCULAR BIOLOGY | 2000年 / 20卷 / 09期

关键词：

arginine; nitric oxide; atherosclerosis; vasodilation;

D O I：

10.1161/01.ATV.20.9.2032

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Asymmetric dimethylarginine (ADMA) is an endogenous and competitive inhibitor of nitric oxide synthase. Plasma levels of this inhibitor are elevated in patients with atherosclerosis and in those with risk factors for atherosclerosis. In these patients, plasma ADMA levels are correlated with the severity of endothelial dysfunction and atherosclerosis, By inhibiting the production of nitric oxide, ADMA may impair blood flow, accelerate atherogenesis, and interfere with angiogenesis. ADMA may be a novel risk factor for vascular disease.

引用

收藏

页码：2032 / 2037

页数：6

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