Drug and gene delivery and enhancement of thrombolysis using ultrasound and microbubbles

被引：26

作者：

Tsutsui, JM

Grayburn, PA

Xie, F

Porter, TR

机构：

[1] Univ Nebraska, Med Ctr, Dept Internal Med, Cardiol Sect, Omaha, NE 68198 USA

[2] Baylor Univ, Med Ctr, Dept Internal Med, Baylor Hear & Vasc Inst, Dallas, TX 75226 USA

来源：

CARDIOLOGY CLINICS | 2004年 / 22卷 / 02期

关键词：

D O I：

10.1016/j.ccl.2004.02.009

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

This article reviews some important characteristics of microbubbles that give them therapeutic properties. It discusses the use of microbubbles and ultrasound for targeted delivery of adenovirus and nonviral vectors to myocytes and endothelial cells and for the dissolution of thrombus or potentiation of fibrinolytic agents for acutely thrombosed vessels. Potential applications, such as induction of angiogenesis, inhibition of neointimal hyperplasia, and in the setting of acute myocardial infarction and ischemic stroke, are discussed briefly.

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页码：299 / +

页数：15

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