BRCA1-positive patients are small for gestational age compared with their unaffected relatives

被引：19

作者：

Jernström, H ^{[1
]}

Johannsson, O ^{[1
]}

Borg, Å ^{[1
]}

Ivarsson, H ^{[1
]}

Olsson, H ^{[1
]}

机构：

[1] Univ Lund Hosp, Dept Oncol, S-22185 Lund, Sweden

来源：

EUROPEAN JOURNAL OF CANCER | 1998年 / 34卷 / 03期

关键词：

BRCA1; birth weight; birth length;

D O I：

10.1016/S0959-8049(97)10088-0

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

The BRCA1 gene is thought to exert its main function early in life. We, therefore, studied the effects of BRCA1 mutations on birth weight and birth length. This was carried out by comparing 33 women with and without mutations. Birth weight and length were obtained from a self-administered questionnaire. BRCA1 mutation carriers had a significantly lower birth weight (P = 0.0041) compared with non-carriers, after adjustment for gestational age. They were also significantly shorter at birth compared with their unaffected relatives (P = 0.0060), after adjustment for gestational age. The BRCA1 gene thus seems to influence the carriers in utero. The findings could imply that humans heterozygotic for the BRCA1 mutations may be influenced by the mutations during development in utero. (C) 1998 Published by Elsevier Science Ltd. All rights reserved.

引用

页码：368 / 371

页数：4

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