Cell biology - How cells handle cholesterol

被引：1071

作者：

Simons, K

Ikonen, E

机构：

[1] Max Planck Inst Mol Cell Biol & Genet, D-01307 Dresden, Germany

[2] Natl Publ Hlth Inst, Dept Biochem, Helsinki 00300, Finland

来源：

SCIENCE | 2000年 / 290卷 / 5497期

关键词：

D O I：

10.1126/science.290.5497.1721

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Cholesterol plays an indispensable role in regulating the properties of cell membranes in mammalian cells. Recent advances suggest that cholesterol exerts many of its actions mainly by maintaining sphingolipid rafts in a functional state. How rafts contribute to cholesterol metabolism and transport in the cell is still an open issue. It has Long been known that cellular cholesterol Levels are precisely controlled by biosynthesis, efflux from cells, and influx of Lipoprotein cholesterol into cells. The regulation of cholesterol homeostasis is now receiving a new focus, and this changed perspective may throw Light on diseases caused by cholesterol excess, the prime example being atherosclerosis.

引用

页码：1721 / 1726

页数：6

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