Role of IL-6 in cytokine-induced sickness behavior:: a study with IL-6 deficient mice

被引:189
作者
Bluthé, RM
Michaud, B
Poli, V
Dantzer, R
机构
[1] INSERM, INRA, U394, Inst Francois Magendie, F-33077 Bordeaux, France
[2] Univ Dundee, Dept Biochem, Dundee DD1 4HN, Scotland
关键词
interleukin-1; interleukin-6; brain; lipopolysaccharide; behavior; body weight; knock-out mice;
D O I
10.1016/S0031-9384(00)00269-9
中图分类号
B84 [心理学];
学科分类号
04 ; 0402 ;
摘要
Interleukin-6 (IL-6) is synthesized and released in response to the cytokine inducer lipopolysaccharide (LPS) and IL-1, and acts as an endogenous pyrogen. Systemic administration of LPS and IL-1 to mice induces signs of sickness, including reduction of social exploration, immobility and body weight loss. To assess the role of IL-6 in the induction of sickness behavior, male IL-6-deficient mice (IL-6 -/-, Balb/cAn genetic background) were used and compared to IL-6 +/+ littermates. The depressing effects of intraperitoneal LPS (2.5 mu g/ mouse) and IL-1 beta (1.0 mu g/mouse) on behavior and change in body weight were more marked in IL-6 +/+ than in IL-6 -/- mice. The same difference was observed when mice were injected with LPS (5 ng/mouse) and IL-1 beta (1 ng/mouse) into the lateral ventricle of the brain (i.c.v.). These results show that IL-6 released at the periphery and/or in the central nervous system plays a role in the behavioral response to LPS and IL-1. (C) 2000 Elsevier Science inc. All rights reserved.
引用
收藏
页码:367 / 373
页数:7
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