TLR2 and TLR4 in Ischemia Reperfusion Injury

被引:148
作者
Arslan, F. [2 ]
Keogh, B. [1 ]
McGuirk, P. [1 ]
Parker, A. E. [1 ]
机构
[1] Opsona Therapeut Ltd, Inst Mol Med, Trinity Ctr Hlth Sci, St James Hosp, Dublin 8, Ireland
[2] Univ Med Ctr Utrecht, Lab Expt Cardiol, NL-3584 CX Utrecht, Netherlands
关键词
TOLL-LIKE RECEPTOR; NF-KAPPA-B; ISCHEMIA/REPERFUSION INJURY; INNATE IMMUNITY; LIVER-TRANSPLANTATION; MYOCARDIAL-ISCHEMIA; DENDRITIC CELLS; DOWN-REGULATION; RENAL INJURY; IFN-GAMMA;
D O I
10.1155/2010/704202
中图分类号
Q2 [细胞生物学];
学科分类号
071009 ; 090102 ;
摘要
Ischemia reperfusion (I/R) injury refers to the tissue damage which occurs when blood supply returns to tissue after a period of ischemia and is associated with trauma, stroke, myocardial infarction, and solid organ transplantation. Although the cause of this injury is multifactorial, increasing experimental evidence suggests an important role for the innate immune system in initiating the inflammatory cascade leading to detrimental/deleterious changes. The Toll-like Receptors (TLRs) play a central role in innate immunity recognising both pathogen-and damage-associated molecular patterns and have been implicated in a range of inflammatory and autoimmune diseases. In this paper, we summarise the current state of knowledge linking TLR2 and TLR4 to I/R injury, including recent studies which demonstrate that therapeutic inhibition of TLR2 has beneficial effects on I/R injury in a murine model of myocardial infarction.
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页数:8
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