Brief report: Fatal avian influenza A (H5N1) in a child presenting with diarrhea followed by coma

被引:378
作者
de Jong, MD [1 ]
Van Cam, B
Qui, PT
Hien, VM
Thanh, TT
Hue, NB
Beld, M
Phuong, LT
Khanh, TH
Chau, NVV
Hien, TT
Ha, DQ
Farrar, J
机构
[1] Univ Oxford, Clin Res Unit, Hosp Trop Dis, Ho Chi Minh City, Vietnam
[2] Paediat Hosp One, Ho Chi Minh City, Vietnam
[3] Univ Amsterdam, Acad Med Ctr, NL-1105 AZ Amsterdam, Netherlands
[4] Dong Thap Hosp, Cao Lanh, Vietnam
关键词
D O I
10.1056/NEJMoa044307
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
In southern Vietnam, a four-year-old boy presented with severe diarrhea, followed by seizures, coma, and death. The cerebrospinal fluid contained 1 white cell per cubic millimeter, normal glucose levels, and increased levels of protein (0.81 g per liter). The diagnosis of avian influenza A (H5N1) was established by isolation of the virus from cerebrospinal fluid, fecal, throat, and serum specimens. The patient's nine-year-old sister had died from a similar syndrome two weeks earlier. In both siblings, the clinical diagnosis was acute encephalitis. Neither patient had respiratory symptoms at presentation. These cases suggest that the spectrum of influenza H5N1 is wider than previously thought.
引用
收藏
页码:686 / 691
页数:6
相关论文
共 24 条
[1]  
Apisarnthanarak A, 2004, EMERG INFECT DIS, V10, P1321
[2]   Highly sensitive assay for detection of enterovirus in clinical specimens by reverse transcription-PCR with an armored RNA internal control [J].
Beld, M ;
Minnaar, R ;
Weel, J ;
Sol, C ;
Damen, M ;
van der Avoort, H ;
Wertheim-van Dillen, P ;
van Breda, A ;
Boom, R .
JOURNAL OF CLINICAL MICROBIOLOGY, 2004, 42 (07) :3059-3064
[3]   The evolution of H5N1 influenza viruses in ducks in southern China [J].
Chen, H ;
Deng, G ;
Li, Z ;
Tian, G ;
Li, Y ;
Jiao, P ;
Zhang, L ;
Liu, Z ;
Webster, RG ;
Yu, K .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (28) :10452-10457
[4]   Distinct pathogenesis of hong kong-origin H5N1 viruses in mice compared to that of other highly pathogenic H5 avian influenza viruses [J].
Dybing, JK ;
Schultz-Cherry, S ;
Swayne, DE ;
Suarez, DL ;
Perdue, ML .
JOURNAL OF VIROLOGY, 2000, 74 (03) :1443-1450
[5]   PCR on cerebrospinal fluid to show influenza-associated acute encephalopathy or encephalitis [J].
Fujimoto, S ;
Kobayashi, M ;
Uemura, O ;
Iwasa, M ;
Ando, T ;
Katoh, T ;
Nakamura, G ;
Maki, N ;
Togari, H ;
Wada, Y .
LANCET, 1998, 352 (9131) :873-875
[6]   Biological heterogeneity, including systemic replication in mice, of H5N1 influenza A virus isolates from humans in Hong Kong [J].
Gao, P ;
Watanabe, S ;
Ito, T ;
Goto, H ;
Wells, K ;
McGregor, M ;
Cooley, AJ ;
Kawaoka, Y .
JOURNAL OF VIROLOGY, 1999, 73 (04) :3184-3189
[7]   H5N1 influenza: A protean pandemic threat [J].
Guan, Y ;
Poon, LLM ;
Cheung, CY ;
Ellis, TM ;
Lim, W ;
Lipatov, AS ;
Chan, KH ;
Sturm-Ramirez, KM ;
Cheung, CL ;
Leung, YHC ;
Yuen, KY ;
Webster, RG ;
Peiris, JSM .
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2004, 101 (21) :8156-8161
[8]   Avian influenza A (H5N1) in 10 patients in Vietnam. [J].
Hien, TT ;
Liem, NT ;
Dung, NT ;
San, LT ;
Mai, PP ;
Chau, NVV ;
Suu, PT ;
Dong, VC ;
Mai, LTQ ;
Thi, NT ;
Khoa, DB ;
Phat, LP ;
Truong, NT ;
Long, HT ;
Tung, CV ;
Giang, LT ;
Tho, ND ;
Nga, LH ;
Tien, NTK ;
San, LH ;
Tuan, LV ;
Dolecek, C ;
Thanh, TT ;
de Jong, M ;
Schultsz, C ;
Cheng, P ;
Lim, W ;
Horby, P ;
Farrar, J .
NEW ENGLAND JOURNAL OF MEDICINE, 2004, 350 (12) :1179-1188
[9]   Avian influenza H5N1 in tigers and leopards [J].
Keawcharoen, J ;
Oraveerakul, K ;
Kuiken, T ;
Fouchier, RAM ;
Amonsin, A ;
Payungporn, S ;
Noppornpanth, S ;
Wattanodorn, S ;
Theamboonlers, A ;
Tantilertcharoen, R ;
Pattanarangsan, R ;
Arya, M ;
Ratanakorn, P ;
Osterhaus, ADME ;
Poovorawan, Y .
EMERGING INFECTIOUS DISEASES, 2004, 10 (12) :2189-2191
[10]   PROVED VIRAEMIA IN ASIAN INFLUENZA (HONG KONG VARIANT) DURING INCUBATION PERIOD [J].
KHAKPOUR, M ;
SAIDI, A ;
NAFICY, K .
BRITISH MEDICAL JOURNAL, 1969, 4 (5677) :208-&