Protein aggregation: folding aggregates, inclusion bodies and amyloid

被引：1019

作者：

Fink, AL ^{[1
]}

机构：

[1] Univ Calif Santa Cruz, Dept Chem & Biochem, Santa Cruz, CA 95064 USA

来源：

FOLDING & DESIGN | 1998年 / 3卷 / 01期

基金：

美国国家科学基金会;

关键词：

D O I：

10.1016/S1359-0278(98)00002-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Aggregation results in the formation of inclusion bodies, amyloid fibrils and folding aggregates. Substantial data support the hypothesis that partially folded intermediates are key precursors to aggregates, that aggregation involves specific intermolecular interactions and that most aggregates involve beta sheets.

引用

页码：R9 / R23

页数：15

共 158 条

[1] Refolding intermediates of acid-unfolded mitochondrial aspartate aminotransferase bind to hsp70 [J].

Artigues, A ;

Iriarte, A ;

MartinezCarrion, M .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1997, 272 (27) :16852-16861

[2] DOMAIN SWAPPING - ENTANGLING ALLIANCES BETWEEN PROTEINS [J].

BENNETT, MJ ;

CHOE, S ;

EISENBERG, D .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1994, 91 (08) :3127-3131

[3] Synchrotron X-ray studies suggest that the core of the transthyretin amyloid fibril is a continuous beta-sheet helix [J].

Blake, C ;

Serpell, L .

STRUCTURE, 1996, 4 (08) :989-998

[4] DNAK-MEDIATED ALTERATIONS IN HUMAN GROWTH-HORMONE PROTEIN INCLUSION-BODIES [J].

BLUM, P ;

VELLIGAN, M ;

LIN, N ;

MATIN, A .

BIO-TECHNOLOGY, 1992, 10 (03) :301-304

[5] Instability, unfolding and aggregation of human lysozyme variants underlying amyloid fibrillogenesis [J].

Booth, DR ;

Sunde, M ;

Bellotti, V ;

Robinson, CV ;

Hutchinson, WL ;

Fraser, PE ;

Hawkins, PN ;

Dobson, CM ;

Radford, SE ;

Blake, CCF ;

Pepys, MB .

NATURE, 1997, 385 (6619) :787-793

[6]

BOWDEN GA, 1990, J BIOL CHEM, V265, P16760

[7] STRUCTURE AND MORPHOLOGY OF PROTEIN INCLUSION-BODIES IN ESCHERICHIA-COLI [J].

BOWDEN, GA ;

PAREDES, AM ;

GEORGIOU, G .

BIO-TECHNOLOGY, 1991, 9 (08) :725-730

[8]

BREMS DN, 1990, J BIOL CHEM, V265, P5504

[9]

BREMS DN, 1987, J BIOL CHEM, V262, P2590

[10] FOLDING OF BOVINE GROWTH-HORMONE IS CONSISTENT WITH THE MOLTEN GLOBULE HYPOTHESIS [J].

BREMS, DN ;

HAVEL, HA .

PROTEINS-STRUCTURE FUNCTION AND GENETICS, 1989, 5 (01) :93-95

← 1 2 3 4 5 6 7 8 9 10 →