Rapid neural differentiation of human cord blood-derived mesenchymal stem cells

被引：116

作者：

Jeong, JA ^{[1
]}

Gang, EJ ^{[1
]}

Hong, SH ^{[1
]}

Hwang, SH ^{[1
]}

Kim, SW ^{[1
]}

Yang, HI ^{[1
]}

Ahn, C ^{[1
]}

Han, H ^{[1
]}

Kim, H ^{[1
]}

机构：

[1] Histostem Co, Biotechnol Res Inst, Seoul 134060, South Korea

来源：

NEUROREPORT | 2004年 / 15卷 / 11期

关键词：

human umbilical cord blood; mesenchymal stem cells; neural differentiation;

D O I：

10.1097/01.wnr.0000134846.79002.5c

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Human umbilical cord blood (UCB) contains hematopoietic stem cells (HSCs) and mesenchymal stem cells (HSCs), both of which are regarded as valuable sources for cell transplantation and cell therapy. Adherent cells expressing MSCs-related antigens such as SH2, CD13, CD29, and ASMA, have been isolated from a mononuclear cell fraction of human UCB. Under proneurogenic conditions, these UCB-derived adherent cells rapidly assumed the morphology of multipolar neurons. Both immunofluorescence and RT-PCR analyses indicated that the expression of a number of neural markers including TujI, TrkA, GFAP and CNPases, was markedly elevated during this acute differentiation. The neurogenic potential of UCB-derived may facilitate stem cell therapeutic approaches to neurodegenerative diseases.

引用

页码：1731 / 1734

页数：4

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