SCOOP: a simple method for identification of novel protein superfamily relationships

被引：32

作者：

Bateman, Alex ^{[1
]}

Finn, Robert D. ^{[1
]}

机构：

[1] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, England

来源：

BIOINFORMATICS | 2007年 / 23卷 / 07期

基金：

英国惠康基金;

关键词：

D O I：

10.1093/bioinformatics/btm034

中图分类号：

Q5 [生物化学];

学科分类号：

071010 [生物化学与分子生物学]; 081704 [应用化学];

摘要：

Motivation: Profile searches of sequence databases are a sensitive way to detect sequence relationships. Sophisticated profile-profile comparison algorithms that have been recently introduced increase search sensitivity even further. Results: In this article, a simpler approach than profile-profile comparison is presented that has a comparable performance to state-of-the-art tools such as COMPASS, HHsearch and PRC. This approach is called SCOOP (Simple Comparison Of Outputs Program), and is shown to find known relationships between families in the Pfam database as well as detect novel distant relationships between families. Several novel discoveries are presented including the discovery that a domain of unknown function (DUF283) found in Dicer proteins is related to double-stranded RNA-binding domains.

引用

页码：809 / 814

页数：6

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