Are serum cholesterol levels associated with silent brain infarcts? The Seiryo Clinic Study

被引：26

作者：

Asumi, Mihoko ^{[1
,2
,3
]}

Yamaguchi, Tatsuo ^{[2
,4
]}

Saito, Kazumi ^{[1
]}

Kodama, Satoru ^{[1
]}

Miyazawa, Hidemitsu ^{[2
]}

Matsui, Hiroshige ^{[2
]}

Suzuki, Emiko ^{[3
]}

Fukuda, Hiroshi ^{[4
]}

Sone, Hirohito ^{[1
]}

机构：

[1] Univ Tsukuba, Inst Clin Med, Dept Internal Med, Mito, Ibaraki 3100015, Japan

[2] Sendai Seiryo Clin, Diagnost Imaging Ctr, Dept Radiol, Sendai, Miyagi, Japan

[3] Ochanomizu Univ, Dept Lifestyle Med, Tokyo 112, Japan

[4] Tohoku Univ, Dept Radiol & Nucl Med, IDAC, Sendai, Miyagi 980, Japan

来源：

ATHEROSCLEROSIS | 2010年 / 210卷 / 02期

基金：

日本学术振兴会;

关键词：

Cerebral infarction; Magnetic resonance imaging; Cholesterol; Multivariate analysis; CEREBRAL INFARCTION; WHITE-MATTER; RISK-FACTORS; METAANALYSIS; PREVALENCE;

D O I：

10.1016/j.atherosclerosis.2010.01.008

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Objective: High levels of serum cholesterol are associated with the risk of stroke. However, the association of serum cholesterol with silent brain infarcts (SBIs) is unclear. We investigated the association between SBI and various clinical factors. Methods: We conducted a cross-sectional study that included 324 apparently healthy Japanese men(mean age 53.8 +/- 9.2 years). Combinations of three types of scan (T1-weighted, T2-weighted and FLAIR images) were used to detect and discriminate SBI. Results: Serum cholesterol was significantly associated with SBI [total cholesterol, odds ratio (OR) 3.75 (95% confidence interval (CI) 1.45-9.68); LDL-cholesterol, OR 2.54 (95% CI 1.03-6.27), and non-HDL-cholesterol, OR 2.54 (95% CI 1.03-6.27)] after adjustment for age, smoking status, serum triglycerides, maximal-intima-media thickness, obesity, hypertension, diabetes mellitus, hyperuricemia, coronary heart disease and lipid-lowering agent use. Conclusion: Our cross-sectional data suggest that serum cholesterol levels are associated with SBI independently of known confounders. (c) 2010 Elsevier Ireland Ltd. All rights reserved.

引用

页码：674 / 677

页数：4

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