Embryonic expression of glial cell-line derived neurotrophic factor (GDNF) suggests multiple developmental roles in neural differentiation and epithelial-mesenchymal interactions

被引：200

作者：

Hellmich, HL

Kos, L

Cho, ES

Mahon, KA

Zimmer, A

机构：

[1] NIMH,CELL BIOL LAB,DEV BIOL UNIT,BETHESDA,MD 20892

[2] NICHHD,LAB MAMMALIAN GENES & DEV,BETHESDA,MD 20892

来源：

MECHANISMS OF DEVELOPMENT | 1996年 / 54卷 / 01期

关键词：

gene expression; central nervous system; kidney development; intestine development; mesenchyme;

D O I：

10.1016/0925-4773(95)00464-5

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

We describe the cloning of the mouse glial cell line-derived neurotrophic factor (GDNF) gene and its expression during embryogenesis. GDNF is a distant member of the superfamily of TGF-beta related genes that was originally identified on the basis of its striking neurotrophic activity. GDNF is expressed in a highly dynamic pattern in the anterior neuroectoderm during early stages of neurogenesis between E7.5 and E10.5. Beginning at E10.5 GDNF is also expressed in several organs that develop through inductive epithelial-mesenchymal interactions. In those organs, GDNF expression is strictly confined to mesenchymal tissues and is not found in epithelia. Our results suggest multiple roles for GDNF during early stages of neuronal development and in epithelial-mesenchymal interactions.

引用

页码：95 / 105

页数：11

共 42 条

[1]

[Anonymous], 1994, Basic Methods In Molecular Biology

[2] MESENCEPHALIC DOPAMINERGIC-NEURONS PROTECTED BY GDNF FROM AXOTOMY-INDUCED DEGENERATION IN THE ADULT BRAIN [J].