Thyrotropin-releasing hormone stimulates phosphorylation of the epidermal growth factor receptor in GH3 pituitary cells

被引：32

作者：

Wang, YH ^{[1
]}

Jue, SF ^{[1
]}

Maurer, RA ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Dept Cell & Dev Biol, Portland, OR 97201 USA

来源：

MOLECULAR ENDOCRINOLOGY | 2000年 / 14卷 / 09期

关键词：

D O I：

10.1210/me.14.9.1328

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

TRH has been found to stimulate tyrosine phosphorylation of the epidermal growth factor (EGF) receptor. A specific EGF receptor kinase inhibitor, tyrphostin AG1478, substantially reduced TRH-stimulated tyrosine phosphorylation of the EGF receptor. TRH-induced EGF receptor phosphorylation was found to lead to the recruitment of the adapter proteins Grb2 and Shc. TRH treatment also led to phosphorylation of the related receptor tyrosine kinase, HERS. HER2 activation likely contributes to downstream signaling events and enhances EGF receptor action. TRH-induced tyrosine phosphorylation of the EGF receptor was reduced by incubation with a protein kinase C (PKC) kinase inhibitor, GF109203X. EGF receptor phosphorylation was required for full TRH-induced activation of mitogen-activated protein kinase (MAPK) and stimulation of specific transcriptional responses.

引用

页码：1328 / 1337

页数：10

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