A new classification for HIV-1

被引：681

作者：

Berger, EA

Doms, RW

Fenyö, EM

Korber, BTM

Littman, DR

Moore, JP

Sattentau, QJ

Schuitemaker, H

Sodroski, J

Weiss, RA

机构：

[1] NIAID, Viral Dis Lab, NIH, Bethesda, MD 20892 USA

[2] Univ Penn, Dept Pathol & Lab Med, Philadelphia, PA 19104 USA

[3] Karolinska Inst, Microbiol & Tumorbiol Ctr, EC Concerted Act HIV Variat, S-17177 Stockholm, Sweden

[4] Univ Calif Los Alamos Natl Lab, Los Alamos, NM 87545 USA

[5] NYU, Med Ctr, Howard Hughes Med Inst, New York, NY 10016 USA

[6] Rockefeller Univ, Aaron Diamond AIDS Res Ctr, New York, NY 10016 USA

[7] Ctr Immunol Marseille Luminy, F-13288 Marseille, France

[8] Netherlands Red Cross, Blood Transfus Serv, Cent Lab, Dept Clin Viroimmunol, Amsterdam, Netherlands

[9] Univ Amsterdam, Expt & Clin Immunol Lab, Amsterdam, Netherlands

[10] Dana Farber Canc Inst, Dept Canc Immunol AIDS, Boston, MA 02115 USA

[11] Inst Canc Res, Chester Beatty Labs, London SW3 6JB, England

来源：

NATURE | 1998年 / 391卷 / 6664期

关键词：

D O I：

10.1038/34571

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The phenotype of HIV-1 isolates is defined by the cells in which they replicate in vitro, but these phenotypes can change in vivo with profound implications for viral transmission, pathogenesis and disease progression. Here we propose a new classification system based on co-receptor use, providing a more accurate description of viral phenotype than the present imprecise and often misleading classification schemes.

引用

页码：240 / 240

页数：1

共 10 条

[1]

Berger EA, 1997, AIDS, V11, pS3

[2] HUMAN-IMMUNODEFICIENCY-VIRUS TYPE-1 VARIANTS WITH INCREASED REPLICATIVE CAPACITY DEVELOP DURING THE ASYMPTOMATIC STAGE BEFORE DISEASE PROGRESSION [J].