Telomere states and cell fates

被引：1078

作者：

Blackburn, EH ^{[1
]}

机构：

[1] Univ Calif San Francisco, Dept Biochem, San Francisco, CA 94143 USA

[2] Univ Calif San Francisco, Dept Microbiol, San Francisco, CA 94143 USA

来源：

NATURE | 2000年 / 408卷 / 6808期

关键词：

D O I：

10.1038/35040500

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Telomere length has frequently been used as a means to predict the future life of cells. But by itself it can be a poor indicator of ageing or cell viability. What, then, is the important property of a telomere? Here recent findings are integrated into a new, probabilistic view of the telomere to explain how and when it can signal not only its own fate but also that of a cell.

引用

页码：53 / 56

页数：4

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