Orchestrating nuclear functions: ubiquitin sets the rhythm

被引：51

作者：

Bach, I ^{[1
]}

Ostendorff, HP ^{[1
]}

机构：

[1] Univ Hamburg, Zentrum Mol Neurobiol ZMNH, D-20251 Hamburg, Germany

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 04期

关键词：

D O I：

10.1016/S0968-0004(03)00055-0

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The nucleus of the eukaryotic cell must carry out many functions simultaneously. These tasks include ensuring that the cell is continuously supplied with an appropriate, changing set of proteins on its way through cell divisions and differentiation. During these processes, the integrity of the genetic material must be maintained against a constant onslaught of damaging physiological and environmental factors. Fulfilling these complex tasks requires the dynamic integration and synchronization of different nuclear functions. Protein modification by ubiquitin is proving to be a crucial tool for nuclear functioning, and is emerging as a decisive mechanism that enables the concerted regulation of nuclear pathways.

引用

页码：189 / 195

页数：7

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