Common variants at 2q37.3, 8q24.21, 15q21.3 and 16q24.1 influence chronic lymphocytic leukemia risk

被引：175

作者：

Crowther-Swanepoel, Dalemari ^{[1
]}

Broderick, Peter ^{[1
]}

Di Bernardo, Maria Chiara ^{[1
]}

Dobbins, Sara E. ^{[1
]}

Torres, Maria ^{[2
,3
]}

Mansouri, Mahmoud ^{[4
]}

Ruiz-Ponte, Clara ^{[2
,3
]}

Enjuanes, Anna ^{[5
]}

Rosenquist, Richard ^{[4
]}

Carracedo, Angel ^{[2
,3
]}

Jurlander, Jesper ^{[6
]}

Campo, Elias ^{[5
]}

Juliusson, Gunnar ^{[7
]}

Montserrat, Emilio ^{[8
]}

Smedby, Karin E. ^{[9
]}

Dyer, Martin J. S. ^{[10
]}

Matutes, Estella ^{[11
]}

Dearden, Claire ^{[11
]}

Sunter, Nicola J. ^{[12
]}

Hall, Andrew G. ^{[12
]}

Mainou-Fowler, Tryfonia ^{[13
]}

Jackson, Graham H. ^{[14
]}

Summerfield, Geoffrey ^{[15
]}

Harris, Robert J. ^{[16
]}

Pettitt, Andrew R. ^{[16
]}

Allsup, David J. ^{[17
]}

Bailey, James R. ^{[18
,19
]}

Pratt, Guy ^{[20
]}

Pepper, Chris ^{[21
]}

Fegan, Chris ^{[22
]}

Parker, Anton ^{[23
]}

Oscier, David ^{[23
]}

Allan, James M. ^{[12
]}

Catovsky, Daniel ^{[11
]}

Houlston, Richard S. ^{[1
]}

机构：

[1] Inst Canc Res, Sect Canc Genet, Sutton, Surrey, England

[2] Univ Santiago de Compostela, Genom Med Grp, Santiago De Compostela, Spain

[3] CIBERER, Galician Fdn Genom Med, Santiago De Compostela, Spain

[4] Uppsala Univ, Dept Genet & Pathol, Uppsala, Sweden

[5] Univ Barcelona, Hematopathol Unit, Ctr Biomed Diag Hosp Clin, Barcelona, Spain

[6] Rigshosp, Leukemia Lab, Dept Hematol, DK-2100 Copenhagen, Denmark

[7] Lund Univ, Lund Strateg Res Ctr Stem Cell Biol & Cell Therap, Lund, Sweden

[8] Univ Barcelona, Dept Hematol, Inst Invest Biomed August Pi & Sunyer, Hosp Clin, Barcelona, Spain

[9] Karolinska Inst, Dept Med, Clin Epidemiol Unit, Stockholm, Sweden

[10] Univ Leicester, MRC, Toxicol Unit, Leicester, Leics, England

[11] Inst Canc Res, Sect Haematooncol, Sutton, Surrey, England

[12] Newcastle Univ, No Inst Canc Res, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[13] Newcastle Univ, Sch Med, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England

[14] Royal Victoria Infirm, Dept Haematol, Newcastle Upon Tyne NE1 4LP, Tyne & Wear, England

[15] Queen Elizabeth Hosp, Dept Haematol, Newcastle Upon Tyne, Tyne & Wear, England

[16] Univ Liverpool, Div Haematol, Sch Canc Studies, Liverpool L69 3BX, Merseyside, England

[17] Hull Royal Infirm, Dept Haematol, Kingston Upon Hull HU3 2JZ, N Humberside, England

[18] Hull York Med Sch, Kingston Upon Hull, N Humberside, England

[19] Univ Hull, Kingston Upon Hull HU6 7RX, N Humberside, England

[20] Birmingham Heartlands Hosp, Dept Haematol, Birmingham B9 5ST, W Midlands, England

[21] Cardiff Univ, Dept Haematol, Sch Med, Cardiff, S Glam, Wales

[22] Cardiff & Vale Natl Hlth Serv Trust, Cardiff, S Glam, Wales

[23] Royal Bournemouth Hosp, Bournemouth, Dorset, England

来源：

NATURE GENETICS | 2010年 / 42卷 / 02期

基金：

英国惠康基金;

关键词：

GENOME-WIDE ASSOCIATION; SUSCEPTIBILITY LOCI; COLORECTAL-CANCER; PROSTATE-CANCER; GENE; FAMILIES; SCAN; IG; METAANALYSIS; NUCLEOTIDE;

D O I：

10.1038/ng.510

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

To identify new risk variants for chronic lymphocytic leukemia (CLL), we conducted a genome-wide association study of 299,983 tagging SNPs, with validation in four additional series totaling 2,503 cases and 5,789 controls. We identified four new risk loci for CLL at 2q37.3 (rs757978, FARP2; odds ratio (OR) = 1.39; P = 2.11 x 10(-9)), 8q24.21 (rs2456449; OR = 1.26; P = 7.84 x 10(-10)), 15q21.3 (rs7169431; OR = 1.36; P = 4.74 x 10(-7)) and 16q24.1 (rs305061; OR = 1.22; P = 3.60 x 10(-7)). We also found evidence for risk loci at 15q25.2 (rs783540, CPEB1; OR = 1.18; P = 3.67 x 10(-6)) and 18q21.1 (rs1036935; OR = 1.22; P = 2.28 x 10(-6)). These data provide further evidence for genetic susceptibility to this B-cell hematological malignancy.

引用

页码：132 / U59

页数：7

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