The emerging role of interferon in human systemic lupus erythematosus

被引：191

作者：

Baechler, EC ^{[1
]}

Gregersen, PK

Behrens, TI

机构：

[1] Univ Minnesota, Sch Med, Dept Med, Ctr Lupus Res, Minneapolis, MN 55455 USA

[2] N Shore Long Isl Jewish Res Inst, Robert S Boas Ctr Genom & Genet, Manhasset, NY USA

来源：

CURRENT OPINION IN IMMUNOLOGY | 2004年 / 16卷 / 06期

关键词：

D O I：

10.1016/j.coi.2004.09.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Recent studies of patients with systemic lupus erythematosus, together with data from lupus-prone mice, suggest that inappropriate activation of type I interferon might have a role in disease pathogenesis. Serum levels of IFN-alpha are elevated in SLE patients, and gene expression profiling of peripheral blood cells shows that most lupus cases demonstrate an upregulation of IFN-responsive genes. Of interest, the I FN gene 'signature' correlates with more severe disease. The available data support a model whereby chromatin-containing immune complexes circulating in the blood of lupus patients stimulate leukocytes to produce IFN, which perpetuates disease. These emerging insights into the connection between IFN and lupus provide a host of new diagnostic and therapeutic opportunities.

引用

页码：801 / 807

页数：7

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