Are changes in integrin affinity and conformation overemphasized?

被引：221

作者：

Bazzoni, G ^{[1
]}

Hemler, ME ^{[1
]}

机构：

[1] Harvard Univ, Sch Med, Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 1998年 / 23卷 / 01期

关键词：

D O I：

10.1016/S0968-0004(97)01141-9

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

The activation of integrin-type adhesion receptors might result in the increased affinity of the receptor for ligand. In addition, the activated receptor might display new epitopes, which are increasingly monitored in clinical settings. Here, we highlight examples of integrin 'activation' that is not accompanied by enhanced ligand binding. Also, we emphasize that the dominant integrin conformational changes occur not with 'activation', but after integrins have already bound ligand.

引用

页码：30 / 34

页数：5

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