CD7 is a differentiation marker that identifies multiple CD8 T cell effector subsets

被引：64

作者：

Aandahl, EM

Sandberg, JK

Beckerman, KP

Taskén, K

Moretto, WJ

Nixon, DF

机构：

[1] Univ Calif San Francisco, Gladstone Inst Virol & Immunol, San Francisco, CA 94141 USA

[2] Univ Oslo, Dept Biochem Med, Oslo, Norway

来源：

JOURNAL OF IMMUNOLOGY | 2003年 / 170卷 / 05期

关键词：

D O I：

10.4049/jimmunol.170.5.2349

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The adaptive immune response of human CD8 T cells to invading pathogens involves the differentiation of naive cells into memory and effector cells. However, the lineage relationship between memory and effector cells and the differentiation of CD8 T cells into distinct subsets of effector cell subpopulations are subjects of considerable debate. CD7 identifies three populations of CD8 T cells: CD7 high (CD7(high)), low (CD7(low)), and negative (CD7(neg)) that translate into subsets with distinct functional properties. The CD7(high) subset contains naive and memory cells and the CD7(low) and CD7(neg) subsets contain effector cells. The effector cells can functionally be divided into cytokine-secreting effector CD8 T cells and lytic effector CD8 T cells. These data provide a model of human CD8 T cell differentiation in which specialized distinct subpopulations can be identified by expression of CD7.

引用

页码：2349 / 2355

页数：7

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