Dissecting the genetic alterations involved in lung carcinogenesis

被引：28

作者：

Sanchez-Cespedes, M ^{[1
]}

机构：

[1] Spanish Natl Canc Ctr, Mol Pathol Program, Madrid 28029, Spain

来源：

LUNG CANCER | 2003年 / 40卷 / 02期

关键词：

lung carcinogenesis; cancer genetics; tumor suppressor genes; oncogenes; molecular markers;

D O I：

10.1016/S0169-5002(03)00033-3

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

During the past two decades, considerable efforts have been devoted to the identification of the genes that drive lung cancer development. In spite of such intense research, only a few genes harboring mutations have been found, thus hindering the improvement in lung cancer treatment. The present review describes the catalog of known genetic alterations and the recent advances in global expression profiles in lung tumors and briefly discusses their use in clinical management. (C) 2003 Elsevier Science Ireland Ltd. All rights reserved.

引用

页码：111 / 121

页数：11

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