Platelet purinergic receptors

被引：126

作者：

Kunapuli, SP ^{[1
]}

Dorsam, RT ^{[1
]}

Kim, S ^{[1
]}

Quinton, TM ^{[1
]}

机构：

[1] Temple Univ, Sch Med, Philadelphia, PA 19140 USA

来源：

CURRENT OPINION IN PHARMACOLOGY | 2003年 / 3卷 / 02期

关键词：

D O I：

10.1016/S1471-4892(03)00007-9

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Activation of P2Y(1) and P2Y(12) receptors, through secreted ADP that is stimulated by agonists such as thrombin., thromboxane and collagen, is a major mechanism of platelet activation. P2X(1) receptors also participate in platelet shape change and potentiation of calcium mobilization. The cloning of the P2Y(12) receptor and its subsequent knockout in mice promises further understanding of its downstream signaling events.

引用

收藏

页码：175 / 180

页数：6

相关论文

共 55 条

[1]

ANDRE P, 2002, BLOOD, V100, P106

[2] Thrombotic thrombocytopenic purpura associated with clopidogrel. [J].

Bennett, CL ;

Connors, JM ;

Carwile, JM ;

Moake, JL ;

Bell, WR ;

Tarantolo, SR ;

McCarthy, LJ ;

Sarode, R ;

Hatfield, AJ ;

Feldman, MD ;

Davidson, CJ ;

Tsai, HM .

NEW ENGLAND JOURNAL OF MEDICINE, 2000, 342 (24) :1773-1777

[3] Novel platelet inhibitors [J].

Bennett, JS .

ANNUAL REVIEW OF MEDICINE, 2001, 52 :161-184

[4]

Boyer JL, 1996, MOL PHARMACOL, V50, P1323

[5] Potentiation of thromboxane A2-induced platelet secretion by Gi signaling through the phosphoinositide-3 kinase pathway [J].

Dangelmaier, C ;

Jin, JG ;

Smith, JB ;

Kunapuli, SP .

THROMBOSIS AND HAEMOSTASIS, 2001, 85 (02) :341-348

[6] The P2Y1 receptor mediates ADP-induced p38 kinase-activating factor generation in human platelets [J].

Dangelmaier, C ;

Jin, JG ;

Daniel, JL ;

Smith, JB ;

Kunapuli, SP .

EUROPEAN JOURNAL OF BIOCHEMISTRY, 2000, 267 (08) :2283-2289

[7] Molecular basis for ADP-induced platelet activation I. Evidence for three distinct ADP receptors on human platelets [J].

Daniel, JL ;

Dangelmaier, C ;

Jin, JG ;

Ashby, B ;

Smith, JB ;

Kunapuli, SP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1998, 273 (04) :2024-2029

[8] Coordinated signaling through both G12/13 and Gi pathways is sufficient to activate GPIIb/IIIa in human platelets [J].

Dorsam, RT ;

Kim, S ;

Jin, JG ;

Kunapuli, SP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2002, 277 (49) :47588-47595

[9] Decreased platelet aggregation, increased bleeding time and resistance to thromboembolism in P2Y1-deficient mice [J].

Fabre, JE ;

Nguyen, MT ;

Latour, A ;

Keifer, JA ;

Audoly, LP ;

Coffman, TM ;

Koller, BH .

NATURE MEDICINE, 1999, 5 (10) :1199-1202

[10] P2Y1-receptors in human platelets which are pharmacologically distinct from P2YADP-receptors [J].

Fagura, MS ;

Dainty, IA ;

McKay, GD ;

Kirk, IP ;

Humphries, RG ;

Robertson, MJ ;

Dougall, IG ;

Leff, P .

BRITISH JOURNAL OF PHARMACOLOGY, 1998, 124 (01) :157-164

← 1 2 3 4 5 6 →