MHC antigen expression in human first trimester spinal cord with implications for clinical transplantation procedures

被引：4

作者：

Åkesson, E

Markling, L

Kjældgaard, A

Falci, S

Ringdén, O

机构：

[1] Huddinge Univ Hosp, Karolinska Inst, Dept NEUROTEC, Novum, S-14186 Huddinge, Sweden

[2] Huddinge Univ Hosp, Karolinska Inst, Dept Clin Immunol, Novum, S-14186 Huddinge, Sweden

[3] Huddinge Univ Hosp, Karolinska Inst, Dept Obstet & Gynecol, Novum, S-14186 Huddinge, Sweden

[4] Craig Hosp, Dept Neurosurg, Denver, CO USA

[5] Huddinge Univ Hosp, Karolinska Inst, Ctr Allogene Stem Cell Transplantat, Novum, S-14186 Huddinge, Sweden

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2000年 / 111卷 / 1-2期

关键词：

human leukocyte antigen I and II; development; spinal cord; lymphocyte co-cultures and gamma-interferon;

D O I：

10.1016/S0165-5728(00)00383-0

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

We report human leukocyte antigen (HLA) class I expression in 5-17% and class II in 0-9% of first trimester human spinal cord cells. After 8 days in culture with gamma -interferon, >87% of the spinal cord cells expressed HLA class II. However, mixed cultures of adult human peripheral lymphocytes and immature human spinal cord cells, showed no induction of lymphocyte proliferation prior to or after gamma -interferon exposure in culture. In conclusion, we report non-immunogenic expression of HLA antigens in the human first trimester spinal cord. (C) 2000 Elsevier Science BN. All rights reserved.

引用

页码：210 / 214

页数：5

共 31 条

[1] Human embryonic spinal cord grafts in adult rat spinal cord cavities:: Survival, growth, and interactions with the host [J].