Circulating cytokines in Alzheimer's disease

被引：132

作者：

Singh, VK ^{[1
]}

Guthikonda, P ^{[1
]}

机构：

[1] Univ Michigan, Sch Med, Dept Psychiat, Ann Arbor, MI 48108 USA

来源：

JOURNAL OF PSYCHIATRIC RESEARCH | 1997年 / 31卷 / 06期

关键词：

D O I：

10.1016/S0022-3956(97)00023-X

中图分类号：

R749 [精神病学];

学科分类号：

100205 ;

摘要：

Immune factors may be involved in the pathophysiology of Alzheimer's disease (AD), a neurodegenerative disease. Since immune activation precedes immune-mediated processes, we measured plasma levels of four selective cytokines: interleukin-6 (IL-6), interleukin-12 (IL-12), interferon-alpha (IFN-alpha), and interferon-gamma (IFN-gamma). The level of IL-6, but not other cytokines, was significantly elevated. The increase of circulating IL-6 indicates immune activation presumably related to pathophysiology of the disease. (C) 1997 Elsevier Science Ltd. All rights reserved.

引用

页码：657 / 660

页数：4

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