Hypergammaglobulinemia and autoantibody induction mechanisms in viral infections

被引：177

作者：

Hunziker, L

Recher, M

Macpherson, AJ

Ciurea, A

Freigang, S

Hengartner, H

Zinkernagel, RM

机构：

[1] Univ Zurich Hosp, Inst Expt Immunol, CH-8091 Zurich, Switzerland

[2] Univ Basel Hosp, CH-4021 Basel, Switzerland

来源：

NATURE IMMUNOLOGY | 2003年 / 4卷 / 04期

关键词：

D O I：

10.1038/ni911

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Polyclonal hypergammaglobulinemia is a characteristic of chronic inflammatory conditions, including persisting viral infections and autoimmune diseases. Here we have studied hypergammaglobulinemia in mice infected with lymphocytic choriomeningitis virus (LCMV), which induces nonspecific immunoglobulins as a result of switching natural IgM specificities to IgG. The process is dependent on help from CD4(+) T cells that specifically recognize LCMV peptides presented by B cells on major histocompatibility complex class II molecules. Thus, hypergammaglobulinemia may arise when specific helper T cells recognize B cells that have processed viral antigens irrespective of the B cell receptor specificity. This nonspecific B cell activation may contribute to antibody-mediated autoimmunity.

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页码：343 / 349

页数：7

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