Mitochondria: execution central

被引：169

作者：

Gottlieb, RA ^{[1
]}

机构：

[1] Scripps Res Inst, La Jolla, CA 92037 USA

来源：

FEBS LETTERS | 2000年 / 482卷 / 1-2期

关键词：

mitochondrion; apoptosis; caspase; cytochrome c; Bcl-2; homolog;

D O I：

10.1016/S0014-5793(00)02010-X

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Mitochondria play an essential function in eukaryotic life and death, They also play a central role in apoptosis regulation, reflected dy the convergence of Bcl-2 family members on the mitochondrial outer membrane, and the presence of 'death factors' in the intermembrane space. Mitochondrial structure and function must be taken into consideration,when evaluating mechanisms for cytochrome c release, The core machinery for caspase activation is conserved from Caenorhabditis elegans to man, and we consider parallels in the role of mitochondria in this process. (C) 2000 Federation of European Biochemical Societies. Published by Elsevier Science B.V. All rights reserved.

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页码：6 / 12

页数：7

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