Domains of rasGAP and rhoGAP are related

被引：17

作者：

Bax, B ^{[1
]}

机构：

[1] Univ London Birkbeck Coll, Dept Crystallog, London WC1E 7HX, England

来源：

NATURE | 1998年 / 392卷 / 6675期

关键词：

D O I：

10.1038/33040

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Guanine-nucleotide-binding (G) proteins are ‘switched off’ by the hydrolysis of their bound GTP. The GTP bound to the G protein Ras is hydrolysed intrinsically at a very slow rate1, so, in vivo, Ras is turned off by GTPase-activating proteins (GAPs). The structures of GTPase-activating domains (GAP domains), which usually occur as parts of larger proteins, indicate that the Ras and Rho families of small G proteins and their GAPs evolved in parallel.

引用

页码：447 / 448

页数：2

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