A tool for functional brain imaging with lifespan compliance

被引：138

作者：

Hill, Ryan M. ^{[1
]}

Boto, Elena ^{[1
]}

Holmes, Niall ^{[1
]}

Hartley, Caroline ^{[2
]}

Seedat, Zelekha A. ^{[1
]}

Leggett, James ^{[1
]}

Roberts, Gillian ^{[1
]}

Shah, Vishal ^{[3
]}

Tierney, Tim M. ^{[4
]}

Woolrich, Mark W. ^{[5
]}

Stagg, Charlotte J. ^{[5
]}

Barnes, Gareth R. ^{[4
]}

Bowtell, Richard R. ^{[1
]}

Slater, Rebeccah ^{[2
]}

Brookes, Matthew J. ^{[1
]}

机构：

[1] Univ Nottingham, Sir Peter Mansfield Imaging Ctr, Sch Phys & Astron, Univ Park, Nottingham NG7 2RD, England

[2] Univ Oxford, John Radcliffe Hosp, Dept Paediat, Oxford OX3 9DU, England

[3] QuSpin Inc, 2011 Cherry St,Unit 112, Louisville, CO 80027 USA

[4] UCL, Wellcome Ctr Human Neuroimaging, UCL Inst Neurol, London WC1N 3AR, England

[5] Univ Oxford, Warneford Hosp, Oxford Ctr Human Brain Act OHBA, Wellcome Ctr Integrat Neuroimaging, Oxford OX3 7JX, England

来源：

NATURE COMMUNICATIONS | 2019年 / 10卷 / 1期

基金：

英国工程与自然科学研究理事会;

关键词：

ELECTRICAL-ACTIVITY; MAGNETOENCEPHALOGRAPHY;

D O I：

10.1038/s41467-019-12486-x

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The human brain undergoes significant functional and structural changes in the first decades of life, as the foundations for human cognition are laid down. However, non-invasive imaging techniques to investigate brain function throughout neurodevelopment are limited due to growth in head-size with age and substantial head movement in young participants. Experimental designs to probe brain function are also limited by the unnatural environment typical brain imaging systems impose. However, developments in quantum technology allowed fabrication of a new generation of wearable magnetoencephalography (MEG) technology with the potential to revolutionise electrophysiological measures of brain activity. Here we demonstrate a lifespan-compliant MEG system, showing recordings of high fidelity data in toddlers, young children, teenagers and adults. We show how this system can support new types of experimental paradigm involving naturalistic learning. This work reveals a new approach to functional imaging, providing a robust platform for investigation of neurodevelopment in health and disease.

引用

页数：11

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