Cytokines and the aging brain - what we don't know might help us

被引：88

作者：

Bodles, AM

Barger, SW ^{[1
]}

机构：

[1] Univ Arkansas Med Sci, Donald W Reynolds Dept Geriatr, Little Rock, AR 72205 USA

[2] Univ Arkansas Med Sci, Dept Neurobiol & Dev Sci, Little Rock, AR 72205 USA

[3] Cent Arkansas Vet Healthcare Syst, Geriatr Res Educ Clin Ctr, Little Rock, AR 72205 USA

来源：

TRENDS IN NEUROSCIENCES | 2004年 / 27卷 / 10期

关键词：

D O I：

10.1016/j.tins.2004.07.011

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Cognitive aspects of aging represent a grave challenge for our societal circumstances as members of the baby-boom generation spiral toward a collective 'senior moment'. In addition, age-related changes in the CNS can contribute to motor deficits and other somatic aberrations. Inflammation and its regulation by cytokines have been connected to many aspects of aging, and mechanisms addressed here provide a rationale for this. Nevertheless, a role for cytokines in normal aging of the human brain has not been confirmed, and it seems to be possible to ameliorate both cognitive decline and cytokine elevation via lifestyle choices. So ignorance of the brain should not prohibit development of successful strategies for delaying or avoiding neurological deficits.

引用

页码：621 / 626

页数：6

共 70 条

[1] Effects of rofecoxib or naproxen vs placebo on Alzheimer disease progression - A randomized controlled trial [J].

Aisen, PS ;

Schafer, KA ;

Grundman, M ;

Pfeiffer, E ;

Sano, M ;

Davis, KL ;

Farlow, MR ;

Jin, S ;

Thomas, RG ;

Thal, LJ .

JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2003, 289 (21) :2819-2826

[2] Inflammation and Alzheimer's disease [J].

Akiyama, H ;

Barger, S ;

Barnum, S ;

Bradt, B ;

Bauer, J ;

Cole, GM ;

Cooper, NR ;

Eikelenboom, P ;

Emmerling, M ;

Fiebich, BL ;

Finch, CE ;

Frautschy, S ;

Griffin, WST ;

Hampel, H ;

Hull, M ;

Landreth, G ;

Lue, LF ;

Mrak, R ;

Mackenzie, IR ;

McGeer, PL ;

O'Banion, MK ;

Pachter, J ;

Pasinetti, G ;

Plata-Salaman, C ;

Rogers, J ;

Rydel, R ;

Shen, Y ;

Streit, W ;

Strohmeyer, R ;

Tooyoma, I ;

Van Muiswinkel, FL ;

Veerhuis, R ;

Walker, D ;

Webster, S ;

Wegrzyniak, B ;

Wenk, G ;

Wyss-Coray, T .

NEUROBIOLOGY OF AGING, 2000, 21 (03) :383-421

[3]

AMMENDOLA R, 1992, J BIOL CHEM, V267, P17944

[4] TUMOR-NECROSIS-FACTOR-ALPHA AND TUMOR-NECROSIS-FACTOR-BETA PROTECT NEURONS AGAINST AMYLOID BETA-PEPTIDE TOXICITY - EVIDENCE FOR INVOLVEMENT OF A KAPPA-B-BINDING FACTOR AND ATTENUATION OF PEROXIDE AND CA2+ ACCUMULATION [J].

BARGER, SW ;

HORSTER, D ;

FURUKAWA, K ;

GOODMAN, Y ;

KRIEGLSTEIN, J ;

MATTSON, MP .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (20) :9328-9332

[5] Activation of microglia by secreted amyloid precursor protein evokes release of glutamate by cystine exchange and attenuates synaptic function [J].

Barger, SW ;

Basile, AS .

JOURNAL OF NEUROCHEMISTRY, 2001, 76 (03) :846-854

[6] MICROGLIAL-PRODUCED NITRIC-OXIDE AND REACTIVE NITROGEN-OXIDES MEDIATE NEURONAL CELL-DEATH [J].

BOJE, KM ;

ARORA, PK .

BRAIN RESEARCH, 1992, 587 (02) :250-256

[7] Neuronal regulation of lifespan: clues from flies and worms [J].

Boulianne, GL .

MECHANISMS OF AGEING AND DEVELOPMENT, 2001, 122 (09) :883-894

[8] Dysregulation between TH1 and TH2 T cell subpopulations in the elderly [J].

Cakman, I ;

Rohwer, J ;

Schutz, RM ;

Kirchner, H ;

Rink, L .

MECHANISMS OF AGEING AND DEVELOPMENT, 1996, 87 (03) :197-209

[9] Hyperoxia-induced changes in antioxidant capacity and the effect of dietary antioxidants [J].

Cao, GH ;

Shukitt-Hale, B ;

Bickford, PC ;

Joseph, JA ;

McEwen, J ;

Prior, RL .

JOURNAL OF APPLIED PHYSIOLOGY, 1999, 86 (06) :1817-1822

[10]

Cartford MC, 2002, J NEUROSCI, V22, P5813

← 1 2 3 4 5 6 7 →