Sphingolipids and gangliosides of the nervous system in membrane function and dysfunction

被引：206

作者：

de Chaves, Elena Posse ^{[1
]}

Sipione, Simonetta ^{[1
]}

机构：

[1] Univ Alberta, Dept Pharmacol, Edmonton, AB T6G 2H7, Canada

来源：

FEBS LETTERS | 2010年 / 584卷 / 09期

基金：

加拿大创新基金会; 加拿大健康研究院;

关键词：

Sphingolipid; Ganglioside; Ceramide; Sphingomyelin; Membrane; Neurodegeneration; Alzheimer; Parkinson; Huntington's disease; GROWTH-FACTOR RECEPTOR; NECROSIS-FACTOR-ALPHA; GM1; GANGLIOSIDE; ALZHEIMERS-DISEASE; PHOSPHATIDYLINOSITOL; 3-KINASE; LIPIDOMIC ANALYSIS; CELL-ADHESION; CERAMIDE; METABOLISM; PROTEIN;

D O I：

10.1016/j.febslet.2009.12.010

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Simple sphingolipids such as ceramide and sphingomyelin (SM) as well as more complex glycosphingolipids play very important roles in cell function under physiological conditions and during disease development and progression. Sphingolipids are particularly abundant in the nervous system. Due to their amphiphilic nature they localize to cellular membranes and many of their roles in health and disease result from membrane reorganization and from lipid interaction with proteins within cellular membranes. In this review we discuss some of the functions of sphingolipids in processes that entail cellular membranes and their role in neurodegenerative diseases, with an emphasis on SM, ceramide and gangliosides. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B. V. All rights reserved.

引用

页码：1748 / 1759

页数：12

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