The Tudor domain 'Royal Family': Tudor, plant Agenet, Chromo, PWWP and MBT domains

被引：377

作者：

Maurer-Stroh, S

Dickens, NJ

Hughes-Davies, L

Kouzarides, T

Eisenhaber, F

Ponting, CP

机构：

[1] Res Inst Mol Pathol, A-1030 Vienna, Austria

[2] Univ Oxford, Dept Human Anat & Genet, MRC, Funct Genet Unit, Oxford OX1 3QX, England

[3] Univ Cambridge, Wellcome Trust Canc Res UK Inst, Canc Res UK Labs, Cambridge CB2 1QR, England

来源：

TRENDS IN BIOCHEMICAL SCIENCES | 2003年 / 28卷 / 02期

关键词：

D O I：

10.1016/S0968-0004(03)00004-5

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

We have identified a family of 'Agenet' domains that are plant-specific homologs of Tudor domains. This finding has been extended, using a combination of sequence- and structure-dependent approaches, to show that the three beta-stranded core regions of Tudor, PWWP, chromatin-binding (Chromo) and MBT domains are homologous because they originate from a common ancestor. In addition, we have revealed pairs of tandem repeats in the fragile X mental retardation protein (FMRP) family that are also members of this Tudor domain 'Royal Family'.

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页码：69 / 74

页数：6

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