Is familial combined hyperlipidaemia a genetic disorder of adipose tissue?

被引：40

作者：

Arner, P

机构：

[1] Karolinska Institute, Department of Medicine, Huddinge Hospital

来源：

CURRENT OPINION IN LIPIDOLOGY | 1997年 / 8卷 / 02期

关键词：

D O I：

10.1097/00041433-199704000-00006

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Familial combined hyperlipidaemia is a common cause of coronary heart disease. Its aetiology is heterogeneous. The genetic and metabolic basis of the disorder has not yet been defined. This review discusses the putative role of adipose tissue in the pathogenesis of familial combined hyperlipidaemia. It is possible that mutations in genes regulating the turnover of lipids in fat cells are involved in the aetiology.

引用

页码：89 / 94

页数：6

共 34 条

[1]

ABUMRAD NA, 1991, BIOCHEM SOC T, V18, P1130

[2]

AMER P, 1982, J LIPID RES, V23, P422

[3] ADIPOCYTE BETA-ADRENOCEPTOR SENSITIVITY INFLUENCES PLASMA-LIPID LEVELS [J].