Potent and selective inhibitors of the proteasome: Dipeptidyl boronic acids

被引：579

作者：

Adams, J ^{[1
]}

Behnke, M ^{[1
]}

Chen, SW ^{[1
]}

Cruickshank, AA ^{[1
]}

Dick, LR ^{[1
]}

Grenier, L ^{[1
]}

Klunder, JM ^{[1
]}

Ma, YT ^{[1
]}

Plamondon, L ^{[1
]}

Stein, RL ^{[1
]}

机构：

[1] ProScript Inc, Cambridge, MA 02139 USA

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1998年 / 8卷 / 04期

关键词：

D O I：

10.1016/S0960-894X(98)00029-8

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Potent and selective dipeptidyl boronic acid proteasome inhibitors are described. As compared to peptidyl aldehyde compounds, boronic acids in this series display dramatically enhanced potency. Compounds such as 15 are promising new therapeutics for treatment of cancer and inflammatory diseases. (C) 1998 Elsevier Science Ltd. All rights reserved.

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页码：333 / 338

页数：6

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