Mechanisms of resistance to quinolones: target alterations, decreased accumulation and DNA gyrase protection

被引：513

作者：

Ruiz, J ^{[1
]}

机构：

[1] Hosp Clin Barcelona, Dept Microbiol, Inst Clin Infecc & Immunol, E-08036 Barcelona, Spain

来源：

JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | 2003年 / 51卷 / 05期

关键词：

quinolone resistance; DNA gyrase; topoisomerase IV; efflux pumps; qnr;

D O I：

10.1093/jac/dkg222

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Quinolones are broad-spectrum antibacterial agents, commonly used in both clinical and veterinary medicine. Their extensive use has resulted in bacteria rapidly developing resistance to these agents. Two mechanisms of quinolone resistance have been established to date: alterations in the targets of quinolones, and decreased accumulation due to impermeability of the membrane and/or an overexpression of efflux pump systems. Recently, mobile elements have also been described, carrying the qnr gene, which confers resistance to quinolones.

引用

页码：1109 / 1117

页数：9

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