Exogenous NGF restores endogenous NGF distribution in the brain of the cognitively impaired aged rat

被引：27

作者：

Albeck, D

Mesches, MH

Juthberg, S

Browning, M

Bickford, PC

Rose, GM

Granholm, AC

机构：

[1] Univ Colorado, Dept Psychol, Denver, CO 80217 USA

[2] Univ Colorado, Hlth Sci Ctr, Dept Pharmacol, Denver, CO 80262 USA

[3] VA MRS, Denver, CO USA

[4] Umea Univ, Dept Physiol, S-90187 Umea, Sweden

[5] UCHSC, Neurosci Training Program, Denver, CO USA

[6] Ctr Aging & Brain Repair, Tampa, FL USA

[7] Memory Pharmaceut Corp, Montvale, NJ USA

[8] Med Univ S Carolina, Dept Physiol & Neurosci, Charleston, SC 29425 USA

来源：

BRAIN RESEARCH | 2003年 / 967卷 / 1-2期

关键词：

nerve growth factor; cholinergic neuron; basal forebrain; hippocampus;

D O I：

10.1016/S0006-8993(03)02272-8

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Alzheimer's disease and normal aging may impair retrograde transport of nerve growth factor (NGF) from cortical areas to basal forebrain cholinergic neurons. We demonstrate a relationship between performance in a spatial reference memory task and NGF distribution in the aged rat brain. In addition, exogenous NGF restored endogenous NGF distribution in cognitively impaired aged rats. These data suggest that NGF administration restores utilization of endogenous growth factor in the brain of cognitively impaired aged rats. (C) 2003 Elsevier Science B.V. All rights reserved.

引用

收藏

页码：306 / 310

页数：5

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