The chemokine system in diverse forms of macrophage activation and polarization

被引：5277

作者：

Mantovani, A ^{[1
]}

Sica, A

Sozzani, S

Allavena, P

Vecchi, A

Locati, M

机构：

[1] Univ Milan, Inst Gen Pathol, Ctr Eccellenza Innovaz Diagnost & Terapeut, IDET, I-20133 Milan, Italy

[2] Ist Ric Farmacol Mario Negri, I-20157 Milan, Italy

[3] Univ Brescia, Sect Gen Pathol & Immunol, Dept Biotechnol & Biomed Sci, I-25123 Brescia, Italy

来源：

TRENDS IN IMMUNOLOGY | 2004年 / 25卷 / 12期

关键词：

D O I：

10.1016/j.it.2004.09.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Plasticity and functional polarization are hallmarks of the mononuclear phagocyte system. Here we review emerging key properties of different forms of macrophage activation and polarization (M1 M2a, M2b, M2c), which represent extremes of a continuum. In particular, recent evidence suggests that differential modulation of the chemokine system integrates polarized macrophages in pathways of resistance to, or promotion of, microbial pathogens and tumors, or immunoregulation, tissue repair and remodeling.

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收藏

页码：677 / 686

页数：10

相关论文

共 71 条

[1] Toll-like receptor signaling [J].

Akira, S .

JOURNAL OF BIOLOGICAL CHEMISTRY, 2003, 278 (40) :38105-38108

[2] Phenotype, localization, and mechanism of suppression of CD4+CD25+ human thymocytes [J].

Annunziato, F ;

Cosmi, L ;

Liotta, F ;

Lazzeri, E ;

Manetti, R ;

Vanini, V ;

Romagnani, P ;

Maggi, E ;

Romagnani, S .

JOURNAL OF EXPERIMENTAL MEDICINE, 2002, 196 (03) :379-387

[3] Regulation of chemokine mRNA stability by lipopolysaccharide and IL-10 [J].

Biswas, R ;

Datta, S ;

Das Gupta, J ;

Novotny, M ;

Tebo, J ;

Hamilton, TA .

JOURNAL OF IMMUNOLOGY, 2003, 170 (12) :6202-6208

[4] Differential recognition and scavenging of native and truncated macrophage-derived chemokine (macrophage-derived chemokine/CC chemokine ligand 22) by the D6 decoy receptor [J].

Bonecchi, R ;

Locati, M ;

Galliera, E ;

Vulcano, M ;

Sironi, M ;

Fra, AM ;

Gobbi, M ;

Vecchi, A ;

Sozzani, S ;

Haribabu, B ;

Van Damme, J ;

Mantovani, A .

JOURNAL OF IMMUNOLOGY, 2004, 172 (08) :4972-4976

[5] Divergent effects of interleukin-4 and interferon-γ on macrophage-derived chemokine Production:: An amplification circuit of polarized T helper 2 responses [J].

Bonecchi, R ;

Sozzani, S ;

Stine, JT ;

Luini, W ;

D'Amico, G ;

Allavena, P ;

Chantry, D ;

Mantovani, A .

BLOOD, 1998, 92 (08) :2668-2671

[6] Hypoxia selectively inhibits monocyte chemoattractant protein-1 production by macrophages [J].

Bosco, MC ;

Puppo, M ;

Pastorino, S ;

Mi, ZH ;

Melillo, G ;

Massazza, S ;

Rapisarda, A ;

Varesio, L .

JOURNAL OF IMMUNOLOGY, 2004, 172 (03) :1681-1690

[7] Stimulation of toll-like receptor 4 expression in human mononuclear phagocytes by interferon-γ:: a molecular basis for priming and synergism with bacterial lipopolysaccharide [J].

Bosisio, D ;

Polentarutti, N ;

Sironi, M ;

Bernasconi, S ;

Miyake, K ;

Webb, GR ;

Martin, MU ;

Mantovani, A ;

Muzio, M .

BLOOD, 2002, 99 (09) :3427-3431

[8] L-arginine metabolism in myeloid cells controls T-lymphocyte functions [J].

Bronte, V ;

Serafini, P ;

Mazzoni, A ;

Segal, DM ;

Zanovello, P .

TRENDS IN IMMUNOLOGY, 2003, 24 (06) :302-306

[9] Differential regulation of IL-12 and IL-10 gene expression in macrophages by the basic leucine zipper transcription factor c-Maf fibrosarcoma [J].

Cao, SJ ;

Liu, JG ;

Chesi, M ;

Bergsagel, PL ;

Ho, IC ;

Donnelly, RP ;

Ma, XJ .

JOURNAL OF IMMUNOLOGY, 2002, 169 (10) :5715-5725

[10] CCL16/LEC powerfully triggers effector and antigen-presenting functions of macrophages and enhances T cell cytotoxicity [J].

Cappello, P ;

Caorsi, C ;

Bosticardo, M ;

De Angelis, S ;

Novelli, F ;

Forni, G ;

Giovarelli, M .

JOURNAL OF LEUKOCYTE BIOLOGY, 2004, 75 (01) :135-142

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