Arc/Arg3.1 is essential for the consolidation of synaptic plasticity and memories

被引：658

作者：

Plath, Niels

Ohana, Ora

Dammermann, Bjoern

Errington, Mick L.

Schmitz, Dietmar

Gross, Christina

Mao, Xiaosong

Engelsberg, Arne

Mahlke, Claudia

Welzl, Hans

Kobaz, Ursula

Stawrakakis, Anastasia

Fernandez, Esperanza

Waltereit, Robert

Bick-Sander, Anika

Therstappen, Eric

Cooke, Sam F.

Blanquet, Veronique

Wurst, Wolfgang

Salmen, Benedikt

Boesl, Michael R.

Lipp, Hans-Peter

Grant, Seth G. N.

Bliss, Tim V. P.

Wolfer, David P.

Kuhl, Dietmar ^{[1
]}

机构：

[1] Free Univ Berlin, Dept Biol Chem Pharm, D-14195 Berlin, Germany

[2] Ctr Mol Neurobiol, D-20251 Hamburg, Germany

[3] Univ Zurich, Inst Neuroinformat, CH-8057 Zurich, Switzerland

[4] Natl Inst Med Res, London NW7 1AA, England

[5] Univ Zurich, Div Neuroanat & Behav, CH-8057 Zurich, Switzerland

[6] Wellcome Trust Sanger Inst, Hinxton CB10 1SA, Cambs, England

[7] GSF Res Ctr, D-85764 Oberschleissheim, Germany

[8] Neurosci Res Ctr Charite, D-10117 Berlin, Germany

来源：

NEURON | 2006年 / 52卷 / 03期

基金：

英国医学研究理事会;

关键词：

D O I：

10.1016/j.neuron.2006.08.024

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Arc/Arg3.1 is robustly induced by plasticity-producing stimulation and specifically targeted to stimulated synaptic areas. To investigate the role of Arc/Arg3.1 in synaptic plasticity and learning and memory, we generated Arc/Arg3.1 knockout mice. These animals fail to form long-lasting memories for implicit and explicit learning tasks, despite intact short-term memory. Moreover, they exhibit a biphasic alteration of hippocampal long-term potentiation in the dentate gyrus and area CA1 with an enhanced early and absent late phase. In addition, long-term depression is significantly impaired. Together, these results demonstrate a critical role for Arc/Arg3.1 in the consolidation of enduring synaptic plasticity and memory storage.

引用

页码：437 / 444

页数：8

共 42 条

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