Cancer as an evolutionary and ecological process

被引：1140

作者：

Merlo, Lauren M. F.

Pepper, John W.

Reid, Brian J.

Maley, Carlo C.

机构：

[1] Wistar Inst Anat & Biol, Cell & Mol Oncol Program, Philadelphia, PA 19104 USA

[2] Univ Arizona, Dept Ecol & Evolutionary Biol, Tucson, AZ 85721 USA

[3] Fred Hutchinson Canc Res Ctr, Human Biol Div, Seattle, WA 98109 USA

[4] Univ Washington, Dept Med, Seattle, WA 98195 USA

[5] Univ Washington, Dept Genome Sci, Seattle, WA 98195 USA

来源：

NATURE REVIEWS CANCER | 2006年 / 6卷 / 12期

基金：

美国国家卫生研究院;

关键词：

D O I：

10.1038/nrc2013

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Neoplasms are microcosms of evolution. Within a neoplasm, a mosaic of mutant cells compete for space and resources, evade predation by the immune system and can even cooperate to disperse and colonize new organs. The evolution of neoplastic cells explains both why we get cancer and why it has been so difficult to cure. The tools of evolutionary biology and ecology are providing new insights into neoplastic progression and the clinical control of cancer.

引用

收藏

页码：924 / 935

页数：12

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