Computational approaches to cellular rhythms

被引：451

作者：

Goldbeter, A ^{[1
]}

机构：

[1] Free Univ Brussels, Fac Sci, Unite Chronobiol Theor, B-1050 Brussels, Belgium

来源：

NATURE | 2002年 / 420卷 / 6912期

关键词：

D O I：

10.1038/nature01259

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Oscillations arise in genetic and metabolic networks as a result of various modes of cellular regulation. In view of the large number of variables involved and of the complexity of feedback processes that generate oscillations, mathematical models and numerical simulations are needed to fully grasp the molecular mechanisms and functions of biological rhythms. Models are also necessary to comprehend the transition from simple to complex oscillatory behaviour and to delineate the conditions under which they arise. Examples ranging from calcium oscillations to pulsatile intercellular communication and circadian rhythms illustrate how computational biology contributes to clarify the molecular and dynamical bases of cellular rhythms.

引用

页码：238 / 245

页数：8

共 89 条

[1] Generation of oscillations by the p53-Mdm2 feedback loop: A theoretical and experimental study [J].

Bar-Or, RL ;

Maya, R ;

Segel, LA ;

Alon, U ;

Levine, AJ ;

Oren, M .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2000, 97 (21) :11250-11255

[2] Biological rhythms - Circadian clocks limited by noise [J].

Barkai, N ;

Leibler, S .

NATURE, 2000, 403 (6767) :267-268

[3] HYPOPHYSEAL RESPONSES TO CONTINUOUS AND INTERMITTENT DELIVERY OF HYPOTHALAMIC GONADOTROPIN-RELEASING HORMONE [J].

BELCHETZ, PE ;

PLANT, TM ;

NAKAI, Y ;

KEOGH, EJ ;

KNOBIL, E .

SCIENCE, 1978, 202 (4368) :631-633

[4] Elementary and global aspects of calcium signalling [J].

Berridge, MJ .

JOURNAL OF PHYSIOLOGY-LONDON, 1997, 499 (02) :291-306

[5] CONTROL OF OSCILLATING GLYCOLYSIS OF YEAST BY STOCHASTIC, PERIODIC, AND STEADY SOURCE OF SUBSTRATE - MODEL AND EXPERIMENTAL STUDY [J].

BOITEUX, A ;

GOLDBETER, A ;

HESS, B .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1975, 72 (10) :3829-3833

[6] 3-DIMENSIONAL SCROLL WAVES OF CAMP COULD DIRECT CELL-MOVEMENT AND GENE-EXPRESSION IN DICTYOSTELIUM SLUGS [J].

BRETSCHNEIDER, T ;

SIEGERT, F ;

WEIJER, CJ .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (10) :4387-4391

[7]

CHADWICK DJ, 2000, NOV FDN S, V227

[8] Sensitivity of CaM kinase II to the frequency of Ca2+ oscillations [J].

De Koninck, P ;

Schulman, H .

SCIENCE, 1998, 279 (5348) :227-230

[9] A SINGLE-POOL INOSITOL 1,4,5-TRISPHOSPHATE-RECEPTOR-BASED MODEL FOR AGONIST-STIMULATED OSCILLATIONS IN CA2+ CONCENTRATION [J].

DEYOUNG, GW ;

KEIZER, J .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1992, 89 (20) :9895-9899

[10]

Doedel E.J., 1981, CONGRESSUS NUMERANTI, V30, P25

← 1 2 3 4 5 6 7 8 9 →