Serine phosphorylation of STATs

被引：710

作者：

Decker, T ^{[1
]}

Kovarik, P ^{[1
]}

机构：

[1] Vienna Bioctr, Inst Microbiol & Genet, A-1030 Vienna, Austria

来源：

ONCOGENE | 2000年 / 19卷 / 21期

基金：

奥地利科学基金会;

关键词：

STAT; signal transduction; phosphorylation; MAP kinase;

D O I：

10.1038/sj.onc.1203481

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Tyrosine phosphorylation regulates the dimerization of STATs as an essential prerequisite for the establishment of a classical JAK-STAT signaling path. However, most vertebrate STATs contain a second phosphorylation site within their C-termini, The phosphorylated residue in this case is a serine contained within a P(M)SP motif, and in the majority of situations its mutation to alanine alters transcription factor activity. This review addresses recent advances in understanding the regulation of STAT serine phosphorylation, as well as the kinases and other signal transducers implied in this process. The biochemical and biological consequences of STAT serine phosphorylation are discussed.

引用

页码：2628 / 2637

页数：10

共 74 条

[1] Inhibition of collagenase-3 (MMP-13) expression in transformed human keratinocytes by interferon-γ is associated with activation of extracellular signal-regulated kinase-1,2 and STAT1 [J].

Ala-aho, R ;

Johansson, N ;

Grénman, R ;

Fusenig, NE ;

López-Otín, C ;

Kähäri, VM .

ONCOGENE, 2000, 19 (02) :248-257

[2] Anopheles gambiae Ag-STAT, a new insect member of the STAT family, is activated in response to bacterial infection [J].

Barillas-Mury, C ;

Han, YS ;

Seeley, D ;

Kafatos, FC .

EMBO JOURNAL, 1999, 18 (04) :959-967

[3] Interleukin-2 activation of STAT5 requires the convergent action of tyrosine kinases and a serine/threonine kinase pathway distinct from the Raf1/ERK2 MAP kinase pathway [J].

Beadling, C ;

Ng, J ;

Babbage, JW ;

Cantrell, DA .

EMBO JOURNAL, 1996, 15 (08) :1902-1913

[4] Cooperation of Stat2 and p300/CBP in signalling induced by interferon-alpha [J].

Bhattacharya, S ;

Eckner, R ;

Grossman, S ;

Oldread, E ;

Arany, Z ;

DAndrea, A ;

Livingston, DM .

NATURE, 1996, 383 (6598) :344-347

[5] The mitogen-activated protein (MAP) kinase p38 and its upstream activator MAP kinase kinase 6 are involved in the activation of signal transducer and activator of transcription by hyperosmolarity [J].

Bode, JG ;

Gatsios, P ;

Ludwig, S ;

Rapp, UR ;

Häussinger, D ;

Heinrich, PC ;

Graeve, L .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1999, 274 (42) :30222-30227

[6] STAT3 ACTIVATION BY CYTOKINES UTILIZING GP130 AND RELATED TRANSDUCERS INVOLVES A SECONDARY MODIFICATION REQUIRING AN H7-SENSITIVE KINASE [J].

BOULTON, TG ;

ZHONG, Z ;

WEN, ZL ;

DARNELL, JE ;

STAHL, N ;

YANCOPOULOS, GD .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1995, 92 (15) :6915-6919

[7] Stat3 as an oncogene [J].

Bromberg, JF ;

Wrzeszczynska, MH ;

Devgan, G ;

Zhao, YX ;

Pestell, RG ;

Albanese, C ;

Darnell, JE .

CELL, 1999, 98 (03) :295-303

[8] Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma [J].

Bromberg, JF ;

Horvath, CM ;

Wen, ZL ;

Schreiber, RD ;

Darnell, JE .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (15) :7673-7678

[9] Stat3 activation is required for cellular transformation by v-src [J].

Bromberg, JF ;

Horvath, CM ;

Besser, D ;

Lathem, WW ;

Darnell, JE .

MOLECULAR AND CELLULAR BIOLOGY, 1998, 18 (05) :2553-2558

[10] STAT3 beta, a splice variant of transcription factor STAT3, is a dominant negative regulator of transcription [J].

Caldenhoven, E ;

vanDijk, TB ;

Solari, R ;

Armstrong, J ;

Raaijmakers, JAM ;

Lammers, JWJ ;

Koenderman, L ;

deGroot, RP .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (22) :13221-13227

← 1 2 3 4 5 6 7 8 →