Inconsistencies between maps of human chromosome 22 correlate with increased frequency of disease-related loci

被引：1

作者：

Chelala, C

Debignes, MD

Imbeaud, S

Zoorob, R

Auffray, C

Curis, E

Bénazeth, S

Cox, D

机构：

[1] CNRS, FRE 2571, F-94801 Villejuif, France

[2] Univ Paris 05, Fac Pharm, Lab Biomath, F-75006 Paris, France

[3] Stanford Univ, Sch Med, Dept Genet, Stanford, CA 94305 USA

来源：

JOURNAL OF BIOLOGICAL SYSTEMS | 2002年 / 10卷 / 04期

关键词：

D O I：

10.1142/S0218339002000743

中图分类号：

Q [生物科学];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

The relationships between genetic or radiation hybrid (RH) and sequence maps of chromosome 22 have been reconsidered based on the sequence map. Integrated maps have been constructed by retaining only common markers between genetic or RH maps and the sequence map. Local inversions of markers have been detected. Ratios between either genetic or RH distances and sequence-based distances have been calculated for each map interval. Hot zones for recombination or radiation breakage have been delineated by merging together intervals displaying high distance ratios and located close to each other for sequence-constrained RH maps, and for female and male genetic maps. A statistically significant positive correlation was found between the distribution of disease-related genes and the hot zones for recombination or radiation breakage on both female genetic and Stanford-G3 RH maps. This observation indicates that investigation of chromosomal regions displaying inconsistencies between RH or genetic linkage and sequence-based maps can accelerate the initial phase of identification of disease-associated genes.

引用

页码：303 / 317

页数：15

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