Novel cyclohexyl amides as potent and selective D-3 dopamine receptor ligands

被引：23

作者：

Belliotti, TR

Kesten, SR

Rubin, JR

Wustrow, DJ

Georgic, LM

Zoski, KT

Akunne, HC

Wise, LD

机构：

[1] Parke-Davis Pharmaceutical Research, Division of Warner-Lambert Co., Ann Arbor, MI 48105

来源：

BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 1997年 / 7卷 / 18期

关键词：

D O I：

10.1016/S0960-894X(97)00443-5

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

The dopamine D-3 receptor is an attractive target for the treatment of schizophrenia. We identified PD137557 (V) as a ligand for the D-2 receptor and desired to prepare a selective D3 compound. SAR studies involving different amides and different phenyl piperazines have led to the discovery of 8a and 8c as selective D-3 receptor ligands. (C) 1997 Elsevier Science Ltd.

引用

页码：2403 / 2408

页数：6

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