Paraoxonase: Biochemistry, genetics and relationship to plasma lipoproteins

被引：408

作者：

Mackness, MI

Mackness, B

Durrington, PN

Connelly, PW

Hegele, RA

机构：

[1] UNIV MANCHESTER, MANCHESTER ROYAL INFIRM, DEPT MED, MANCHESTER M13 9WL, LANCS, ENGLAND

[2] ST MICHAELS HOSP, J ALICK LITTLE LIPID RES LAB, TORONTO, ON M5B 1W8, CANADA

来源：

CURRENT OPINION IN LIPIDOLOGY | 1996年 / 7卷 / 02期

关键词：

D O I：

10.1097/00041433-199604000-00004

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

Human serum paraoxonase is located on an HDL. It has the capacity to retard the accumulation of lipid peroxides in LDL under oxidizing conditions in vitro. Paraoxonase has a genetic polymorphism that results in a single amino acid substitution. Evidence indicates that both the serum concentration of paraoxonase and an individual's genotype are related to plasma lipid and lipoprotein concentrations, and possibly also to coronary heart disease, implicating paraoxonase in the development of atherosclerosis.

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页码：69 / 76

页数：8

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